https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Evidence for a critical period in the development of excitability and potassium currents in mouse lumbar superficial dorsal horn neurons https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6928 41%). In older animals (P11–P25) this changed, with AP discharge consisting of brief bursts at current onset (~46% of neurons). Investigation of major subthreshold whole cell currents showed the rapid A-type potassium current (IAr) dominated at all ages examined (90% of neurons at E15–E17, decreasing to >50% after P10). IAr expression levels, based on peak current amplitude, increased during development. Steady-state inactivation and activation for IAr were slightly less potent in E15–E17 versus P21–P25 neurons at potentials near RMP (-55 mV). Together, our data indicate that intrinsic properties and IAr expression change dramatically in SDH neurons during development, with the greatest alterations occurring on either side of a critical period, P6–P10.]]> Sat 24 Mar 2018 08:40:23 AEDT ]]> In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1951 Sat 24 Mar 2018 08:33:18 AEDT ]]> An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1879 Sat 24 Mar 2018 08:31:19 AEDT ]]> Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5822 Sat 24 Mar 2018 07:48:01 AEDT ]]> Moving from an averaged to specific view of spinal cord pain processing circuits https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5804 Sat 24 Mar 2018 07:44:54 AEDT ]]>